Specific ion binding to nonpolar surface patches of proteins.
نویسندگان
چکیده
Employing detailed atomistic modeling we study the mechanisms behind ion binding to proteins and other biomolecules and conclude that (1) small, hard ions bind via direct ion pairing to charged surface groups and (2) large, soft ions bind to nonpolar groups via a solvent assisted attraction. Our predictions are in qualitative agreement with bulk solution data and may provide an important clue for the basic understanding of ion-specific effects in biological systems.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 130 35 شماره
صفحات -
تاریخ انتشار 2008